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KMID : 0387820100170010069
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Clinical Pediatric Hematology-Oncology
2010 Volume.17 No. 1 p.69 ~ p.75
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A Case of Infantile Hepatic Hemangioendothelioma Successfully Treated with Interferon-α
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Lee Jin-Yong
Hwang Su-Jin
Shim Jae-Won
Kim Deok-Soo
Park Moon-Soo
Jung Hye-Lim
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Abstract
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Infantile hemangioendothelioma is a rare benign, but intermediate to aggressive vascular tumor with potentially life-threatening complications such as high output congestive heart failure or Kasabach-Merritt syndrome. IHE is the most common hepatic vascular tumor and the third most common hepatic tumor in children, usually developing in infants less than 6 months of age. Serum alpha-fetoprotein level has been used as an important tumor marker for malignant hepatic tumors such as hepatoblastoma, hepatocellular carcinoma, and germ cell tumors. Steroids and interferon-alpha are two commonly used agents for medical treatment in IHE. We report a 5-month-old female infant with multiple hepatic hemangioendotheliomas associated with elevation of serum alpha-fetoprotein level, who was successfully treated with interferon-alpha.
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KEYWORD
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Infantile hepatic hemangioendothelioma, α-interferon, α-fetoprotein
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